Emerging EPO and EPO receptor regulators and signal transducers
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چکیده
منابع مشابه
Emerging EPO and EPO receptor regulators and signal transducers.
As essential mediators of red cell production, erythropoietin (EPO) and its cell surface receptor (EPO receptor [EPOR]) have been intensely studied. Early investigations defined basic mechanisms for hypoxia-inducible factor induction of EPO expression, and within erythroid progenitors EPOR engagement of canonical Janus kinase 2/signal transducer and activator of transcription 5 (JAK2/STAT5), ra...
متن کاملBlood Spotlight Emerging EPO and EPO receptor regulators and signal transducers
Early parabiotic experiments with anemic and nephrectomized rats predicted the existence of erythropoietin (EPO) as a blood-borne kidney-derived activator of erythropoiesis. Evidence that EPO occurs as a unique glycoprotein hormone was further advanced via arduous fractionations and bioassays of urinary proteins from anemia patients. The purification, partial sequencing, and cloning of erythrop...
متن کاملSelected anti-Epo receptor antibodies predict Epo receptor expression.
In an article recently published in Blood, Elliott et al 1 reported that commercially available anti–erythropoietin receptor (anti-EpoR) antibodies are hardly usable to predict EpoR expression because of their low specificity and affinity. Although we agree with the authors that many of these antibodies work poorly, we strongly disagree with them concerning 2 main points: (1) the ability of San...
متن کاملAnti-Epo receptor antibodies do not predict Epo receptor expression.
Investigators using anti-EpoR antibodies for immunoblotting and immunostaining have reported erythropoietin receptor (EpoR) expression in nonhematopoietic tissues including human tumors. However, these antibodies detected proteins of 66 to 78 kDa, significantly larger than the predicted molecular weight of EpoR (56-57 kDa). We investigated the specificity of these antibodies and showed that the...
متن کاملAnti-erythropoietin (EPO) receptor monoclonal antibodies distinguish EPO-dependent and EPO-independent erythroid progenitors in polycythemia vera.
Erythroid progenitor cells isolated from patients with polycythemia vera (PV) proliferate and differentiate in methylcellulose in the absence of exogenous erythropoietin (EPO). To investigate the potential role of the erythropoietin receptor (EPO-R) in the pathogenesis of PV, we cultured bone marrow-derived or peripheral blood-derived erythroid progenitors in the presence of neutralizing monocl...
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ژورنال
عنوان ژورنال: Blood
سال: 2015
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2014-11-575357